This research paper aimed to identify the human capital drive to social entrepreneurship in Thai context, so we can understand how knowledge and skill that can influence to social entrepreneurship. In addition, this research is also to explore the social entrepreneurship that can describe the experience to create social impact on society in Thailand. Finally, it is to generate the new conceptual framework of social entrepreneurship that can be led to social impact. The sample size for multiple case designs was 5 social entrepreneurs for qualitative research. Semi-interview question is used as a tool to collect data through target group. This research is using grounded approach to analyze the data. Findings show that knowledge and personality are the key point antecedent for human capital that drive to social entrepreneurship. For social entrepreneurship, I have found three more factors that can be used to measure, which are passionate, information seeking, and opportunity seeking. Finally, social impact can be measured in two types that the impact can be seen as the society is increasing on income or profit and improved their quality of living.